Testing Whether LM22A-4 Improves Hippocampal Function in Female MECP2 Heterozygous Mice
Lucas Pozzo-Miller, PhD | University of Alabama Birmingham
Work in the lab of David Katz showed that both acute and chronic administration of LM22A-4 improved respiration in symptomatic female Rett mice. The Pozzo-Miller will test whether this same compound will stabilize the impaired hippocampal network thereby improving synaptic plasticity. The hypothesis is that enhancing TrkB signaling via this drug will improve Rett symptoms.