Outlining the Autonomic Signature of Rett Syndrome

Debra Weese-Mayer, MD & Michael Carroll, PhD | Ann & Robert H. Lurie Children’s Hospital of Chicago

$157,000 AWARDED

Though a substantial effort has been made to understand the autonomic phenotype in Rett through the lens of aggregate measures of heart rate variability, cardiac repolarization and cardiorespiratory coupling, a deep understanding of the dysregulation has been elusive. For these reasons these investigators will apply modern computational tools to a data set of ambulatory physiological measures on a large cohort of young girls with Rett and their matched controls. Evaluation of metrics in fine temporal detail will allow us to define the autonomic signature of Rett syndrome at a level that will help understand the underlying mechanisms, allow clarification of genotype-phenotype correlations and provide a basis for evaluating ongoing clinical interventions.

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