Exploration of the Impact of Cyclodextrin on Lifespan and Brain Cholesterol Metabolism in Male Rett Mice

Stephen Turley, PhD & Adam Lopez, PhD | University of Texas Southwestern Medical Center

$156,180 AWARDED

Recent studies from Monica Justice and Stephen Turley have showed that Rett mice have  increased levels of cholesterol in their brains. Cyclodextrin is currently in clinical trials for Nieman Pick Disease where cholesterol becomes trapped in the brain. Through a mechanism(s) that is not well understood, Cyclodextrin  facilitates the release of cholesterol.  There is now an expanding literature attesting beneficial effects of Cyclo in mouse models for other neurological disorders such as Alzheimer’s disease. Drs. Turley and Lopez are testing Cyclodextrin in Rett mice to see if any improvements can be seen. 

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